Leukemoid Reaction: Leukemoid Causes, Reaction and Treatment!

As a result of stress or infection, the white blood cell count in the bloodstream rises above 50,000 cells per millilitre (as opposed to a primary blood malignancy, such as leukaemia). Immature cells, such as myeloblasts or nucleated red blood cells, are frequently described as being present in the peripheral blood by this term.

Leukemoid Causes

Medical issues are the most common cause of leukemoid reactions, as indicated above. Reactions to leukaemia include: [reference needed]
Significant blood loss (retroperitoneal haemorrhage)


  • using sulfa medications
  • Dapsone administration
  • Gricocorticoid therapy
  • G-CSF or other growth factors can be used.
  • Ricinus communis (Ricinus) (ATRA)
  • Irregularities in the metabolism
  • Infections
  • Difficulty swallowing
  • Tuberculosis
  • Pertussis
  • Mononucleosis is caused by a virus (lymphocyte-predominant)
  • Migration of visceral larvae (eosinophil predominant)
  • Asplenia
  • ketoacidosis is a condition that occurs in people with type 2 diabetes.

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Leukemoid Reaction

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In a leukemoid reaction, the number of white blood cells increases, which can be mistaken for leukaemia. An infection or another condition is likely to blame for the reaction, not cancer. When the underlying problem is treated, the blood counts usually return to normal.

Leukemoid Diagnosis

At least 50,000 WBC/mm3 and an increase in neutrophil precursors are considered leukemoid reactions, according to the traditional definition.

However, there is an abundance of early mature neutrophil precursors, as opposed to the immature forms generally found in acute leukaemia, visible on a peripheral blood smear. A normal or increased level of serum leukocyte alkaline phosphatase indicates a leukemoid reaction, but a low level indicates chronic myelogenous leukaemia. A leukemoid reaction’s bone marrow may be hypercellular but is otherwise ordinary if viewed under the microscope.

leukemoid reaction

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[reference needed] Although leukemoid reactions are normally harmless and do not pose a threat on their own, they are often an indication of a more serious illness (see Causes above). There are many dangerous illnesses that could be mistaken for leukemoid reactions on a peripheral blood smear, such as chronic myelogenous leukaemia (CML). The presence of basophilia and the leukocyte alkaline phosphatase score has traditionally been used to distinguish CML from a leukemoid reaction.

CML can be diagnosed in adults using a variety of tests, the most common of which are tests looking for either the BCR/ABL fusion gene or the Philadelphia chromosome. These tests use cytogenetics and FISH or PCR, respectively. In reactive states, the LAP (Leukocyte Alkaline Phosphatase) score is high; in CML, it is low. An experienced haematologist or oncologist should be sought in circumstances when the diagnosis is not clear cut.

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Leukemoid Treatment

the issue that’s causing all of this When drug-induced symptoms occur, stop taking the drug. Certain anti-neoplastic medications may be recommended if the reaction is found to be caused by something other than drug use.

leukemoid reaction